Technician
Maarten A.H. van Dinther
Curriculum Vitae:
I studied at the laboratory school (HLO, Fontys Eindhoven) from 1996 to 2000. I did my internship at the Radboud University, at the department of microbiology (prof. Huub op den Camp) and was supervised by Harry Harhangi working on an exoglucanase from Piromyces. From 2000 to 2001 I worked as a research technician at Pharming group NV in Leiden, work there focussed on making Flp/Frt and LoxP/CRE recombination cassettes in the casein locus of a bovine ES line for the generation of transgenic cows with recombinant protein expression in the milk. From the end of 2001 I started working in the group of Peter ten Dijke as a research technician. First at the NKI (2001-2004) and later at the LUMC (2005 till present). The work in Peter ten Dijke’s group is focussed on TGFβ and BMP signalling.
Publications
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Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2.
de Miranda NF, van Dinther M, van den Akker BE, van Wezel T, ten Dijke P, Morreau H.
Gastroenterology. 2015 Jun;148(7):1427-37.e8. doi: 10.1053/j.gastro.2015.02.052
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BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis.
Scharpfenecker M, van Dinther M, Liu Z, van Bezooijen RL, Zhao Q, Pukac L, Löwik CW, ten Dijke P.
J Cell Sci. 2007 Mar 15;120(Pt 6):964-72
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The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells.
Deckers M, van Dinther M, Buijs J, Que I, Löwik C, van der Pluijm G, ten Dijke P.
Cancer Res. 2006 Feb 15;66(4):2202-9
