Phd-student
David Nederstigt
Research
SUMOylation is a reversible post-translational modification with major cellular implications, as it regulates for example cell cycle progression, transcription, and nuclear transport through its target proteins. In recent years SUMOylation has been established to also function as a prominent regulator of the immune system. For example, inhibition of SUMOylation was demonstrated to halt cancer cell cycle progression and activate anti-tumor immune responses. We are therefore interested in investigating the interplay between SUMOylation and the immune system.
Curriculum Vitae
I obtained my bachelor’s degree in Life Science & Technology from both Leiden University and Delft University of Technology. Afterwards I completed my master’s degree in Life Science & Technology at Leiden University. Here, I performed two research internships. The first was conducted at the Leiden Institute of Chemistry in the group Supramolecular & Biomaterials Chemistry of prof. dr. Alexander Kros, where we worked on super-resolution imaging of the larval zebrafish blood-brain barrier. The second was performed at the Netherlands Cancer Institute in the group of dr. Tineke Lenstra, where we investigated a DNA label for the dynamic imaging of transcription factors at single loci. In January 2025, I joined the lab of Alfred Vertegaal to study SUMO signaling in immune cells.
